MKV is a container format for holding multiple audio, video, picture, and text data such as subtitle tracks. It is similar to other common containers like MP4 and AVI, although MKV is open in the specification. For video contents, MKV uses a .mkv filename extension, .mka for audios, and .mks for subtitles.
MPC-HC, KMPlayer VLC Media Player MKV File Player MPV
F4V is a filename extension for Flash Video (FLV) container format. It supports H.264 (MPEG-4 AVC) video codec compression standard, which is known to offer significant compression. FLV videos come in multiple formats apart from F4V, including F4P, F4A, and F4B. Also, it opens on Adobe Flash Player 6 or later and Windows Media Player.
Windows Media Player Adobe Flash Player 6 or later Media Monkey